Advantages of DNA Ploidy Analysis Technology in Early Diagnosis of Cervical Cancer

Advantages of DNA Ploidy Analysis Technology in Early Diagnosis of Cervical Cancer:

1、Early Detection: Changes in cellular DNA content are the earliest and most fundamental indication of cellular transformation, serving as an objective, early, and specific marker of cancerous change. The fully automated DNA quantitative analysis system detects and analyzes cellular DNA content to identify cervical cancer and precancerous lesions at an earlier stage.

2、Objectivity: By analyzing and detecting the DNA content of each cell, the system can accurately measure the DNA Index (DI) of every cell, with particular sensitivity to abnormal (aneuploid) cells.

3、Effectiveness: The fully automated DNA quantitative analysis system is an effective detection tool for cervical cancer and precancerous lesions. According to statistics from the 2006 National Cervical Cytology Technology and Diagnosis Symposium, approximately 150,000 people in China had used this detection method. With pathological diagnosis as the reference standard, the DNA screening method achieved a sensitivity of 98.9% and a specificity of 71%.

Product Features:

1、Automatic Image Scanning: Fully automated full-field scanning, automatic focusing, and automatic real-time image capture and storage.

2、Automatic Image Processing: Dynamic grayscale processing of displayed images; uses a genetic algorithm to select 33 optimal parameters from 125 parameters for automatic cell classification.

3、Localized Review: Capable of automatically locating each recorded slide for manual review.

4、High-Efficiency Continuous Operation: The system can process 20 cases per hour and operate continuously for 24 hours.

Clinical Value:

1、Diagnosis of cervical cancer and precancerous lesions;

2、Assessment of the degree of malignancy in cervical cancer;

3、Prediction of the developmental trend of uterine diseases;

4、Supplementing the limitations of cytopathological morphological diagnosis.

How to Prevent Cervical Cancer:

Prevention of cervical cancer primarily relies on screening to achieve early detection, early diagnosis, and early treatment.

1、Promote various forms of health education: advocate late marriage, delayed childbearing, and family planning; emphasize sexual hygiene; and widely disseminate knowledge about cervical cancer.

2、Conduct regular cervical cancer screening. The goal of cervical cancer screening is to identify 90% of early-stage patients through early screening methods. Women with a sexual history of two years or more should undergo cervical cytology examinations. Regular examination is especially important for women with a family history of cervical cancer.

3、Actively treat cervical lesions such as chronic cervicitis, cervical erosion, cervical polyps, and cervical lacerations; be alert to high-risk factors and pay special attention to high-risk patients.

4、When early warning signs of cervical cancer appear (particularly irregular vaginal bleeding, bleeding during intercourse, excessive vaginal discharge, prolonged cervical erosion, or cervicitis), seek medical attention promptly and undergo relevant examinations without delay.

How Should Women of Childbearing Age Undergo Cervical Cancer Screening:

Regarding which women should have cytological examinations and how often, most experts recommend the following:

1、Women without any cervical pathological symptoms or prior relevant conditions should have a cytological examination at least once every two years.

2、All sexually active women should begin regular cytological examinations from the age of 18–20, or within one to two years of first sexual activity.

3、For women over 70 years of age, if they have had two normal results from regular cytological examinations within the past five years, regular screening may be discontinued. However, if they have never had a cytological examination or request one of their own accord, they should undergo the examination.

4、The above recommendations apply only to women without suspicious symptoms or prior medical history, and those with a history of abnormal cytological results who have not been followed up clinically. Women with suspicious symptoms or prior medical history should be managed in accordance with established diagnostic and treatment guidelines.

5、Women who have never been sexually active do not need cytological examinations.

6、For women who became sexually active before the age of 16, clinicians may begin regular cytological examinations before the age of 18 based on the individual situation.

7、Young women (especially those under 30) do not need frequent examinations (e.g., every six months).

8、Women who consistently undergo regular cytological examinations may discontinue at the age of 70.

9、For women who have undergone total hysterectomy, if the cervical portion has not been completely removed, regular smear examinations should still be continued.